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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease myasthenia gravis
Comorbidity C0040100|thymomas
Sentences 6
PubMedID- 26273358 Approximately 40% of thymomas are complicated with myasthenia gravis (mg), significantly relating to type ab, b2, and b3.1 the occurrence of a thymoma complicated with mg may be caused by changes in the thymic microenvironment of tumor formation, and the symptoms of complicated myasthenia are usually more serious than mere mg. although thymomas have a low mortality rate and a low degree of malignancy characteristics, the incidence of second cancers are increased in patients with a thymoma.2 the cause of thymoma is not yet clear, but several studies have indicated that the epstein–barr virus3 and genetic aberration4–8 may play an important role in the pathogenesis of thymomas.
PubMedID- 21879277 Different characteristics of thymomas with and without myasthenia gravis.
PubMedID- 21070986 myasthenia gravis (mg) associated with thymomas differs from nonthymomatous mg, and thymomas associated with mg are also different from non-mg thymomas.
PubMedID- 21092589 The proportion of cd20-positive intra-tumoral b lymphocytes in the group of thymomas with myasthenia gravis was 67.5% (22/40), in contrast to 35.5% (22/62) in those without myasthenia gravis.
PubMedID- 21861913 Calcification in thymomas in association with myasthenia gravis has been stated in 7-25% of patients [3,4,19].
PubMedID- 22966376 We retrospectively studied 73 patients with completely resected thymomas unassociated with myasthenia gravis.

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